Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation.

ABSTRACT:

Background

Adenosine leads to atrial action potential (AP) shortening through activation of adenosine 1 receptors (A₁-R) and subsequent opening of G-protein-coupled inwardly rectifying K⁺ channels. Extracellular production of adenosine is drastically increased during stress and ischemia.

Objective

The aim of this study was to address whether the pharmacological blockade of endogenous production of adenosine and of its signaling prevents atrial fibrillation (AF).

Methods

The role of A₁-R activation on atrial action potential duration, refractoriness, and AF vulnerability was investigated in rat isolated beating heart preparations (Langendorff) with an A₁-R agonist [2-chloro-N ⁶-cyclopentyladenosine (CCPA), 5

SUBMITTER: Soattin L 

PROVIDER: S-EPMC7304385 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature