Exacerbation of autoimmune uveitis by obesity occurs through the melanocortin 5 receptor.

ABSTRACT: Autoimmune uveitis is a leading cause of blindness with a complex etiology. Obesity is considered a chronic disease with a connection with autoimmune diseases through systemic inflammation. However, an obesity and autoimmune disease connection is not consistently true in rodent models of autoimmune disease. A mouse model of human autoimmune uveitis, experimental autoimmune uveitis (EAU) has been used to better understand the immunobiology of uveitis. In this study, we assessed EAU in a high-fat diet (HFD) obesity model and found that the EAU severity is significantly higher in wild-type mice, but not in HFD melanocortin 5 receptor deficient mice. We find a decrease in CD11b⁺ F4/80⁺ Ly-6C^lo Ly-6G⁺ Mϕs, previously shown to be suppressive, and an en

SUBMITTER: Muhammad FY 

PROVIDER: S-EPMC7304441 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature