ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation.

ABSTRACT: When exposed to cold temperatures, mice increase their thermogenic capacity by an expansion of brown adipose tissue mass and the formation of brite/beige adipocytes in white adipose tissue depots. However, the process of the transcriptional changes underlying the conversion of a phenotypic white to brite/beige adipocytes is only poorly understood. By analyzing transcriptome profiles of inguinal adipocytes during cold exposure and in mouse models with a different propensity to form brite/beige adipocytes, we identified ESRRG and PERM1 as modulators of this process. The production of heat by mitochondrial uncoupled respiration is a key feature of brite/beige compared to white adipocytes and we show here that both candidates are involved in PGC1α transcriptional network to positively regulate

SUBMITTER: Muller S 

PROVIDER: S-EPMC7304443 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature