Thinning Faster? Age-Related Cortical Thickness Differences in Adults with Autism Spectrum Disorder.

ABSTRACT:

Background

Over the course of the last 30 years, autism spectrum disorder (ASD) diagnoses have increased, thus identifying a large group of aging individuals with ASD. Currently, little is known regarding how aging will affect these individual's neuroanatomy, compared to the neurotypical (NT) population. Because of the anatomical overlap of ASD-related cortical pathology and age-related cortical thinning, both following an anterior-to-posterior severity gradient, we hypothesize adults with ASD will show larger age-related cortical thinning than NT adults.

Methods

We analyzed cortical measurements using available data from the multi-site Autism Brain Imaging Data Exchange I (ABIDE I; n=282) and our own cohort of middle-age to older adults with and without ASD (n=47) mostly av

SUBMITTER: Braden BB 

PROVIDER: S-EPMC7304569 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature