Associations between mammographic density and tumor characteristics in Chinese women with breast cancer.

ABSTRACT:

Purpose

Mammographic density (MD) is a strong risk factor for breast cancer, yet its relationship with tumor characteristics is not well established, particularly in Asian populations.

Methods

MD was assessed from a total of 2001 Chinese breast cancer patients using Breast Imaging Reporting and Data System (BI-RADS) categories. Molecular subtypes were defined using immunohistochemical status on ER, PR, HER2, and Ki-67, as well as tumor grade. Multinomial logistic regression was used to test associations between MD and molecular subtype (luminal A = reference) adjusting for age, body mass index (BMI), menopausal status, parity, and nodal status.

Results

The mean age at diagnosis was 51.7 years (SD = 10.7) and the average BMI was 24.7 kg/m² (SD = 3.8). The di

SUBMITTER: Li E 

PROVIDER: S-EPMC7304859 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature