Vago-Splenic Axis in Signal Transduction of Remote Ischemic Preconditioning in Pigs and Rats.

ABSTRACT:

Rationale

The signal transduction of remote ischemic conditioning is still largely unknown.

Objective

Characterization of neurohumoral signal transfer and vago-splenic axis in remote ischemic preconditioning (RIPC).

Methods and results

Anesthetized pigs were subjected to 60 minutes of coronary occlusion and 180 minutes of reperfusion (placebo+ischemia/reperfusion [PLA+I/R]). RIPC was induced by 4×5/5 minutes of hindlimb I/R 90 minutes before coronary occlusion (RIPC+I/R). Arterial blood samples were taken after placebo or RIPC before I/R. In subgroups of pigs, bilateral cervical vagotomy, splenectomy, or splenic denervation were performed before PLA+I/R or RIPC+I/R, respectively. In pigs with RIPC+I/R, infarct size (percentage of area at risk) was less than in those w

SUBMITTER: Lieder HR 

PROVIDER: S-EPMC7304918 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature