Literature review and methodological considerations for understanding circulating risk biomarkers following trauma exposure.

ABSTRACT: Exposure to traumatic events is common. While many individuals recover following trauma exposure, a substantial subset develop adverse posttraumatic neuropsychiatric sequelae (APNS) such as posttraumatic stress, major depression, and regional or widespread chronic musculoskeletal pain. APNS cause substantial burden to the individual and to society, causing functional impairment and physical disability, risk for suicide, lost workdays, and increased health care costs. Contemporary treatment is limited by an inability to identify individuals at high risk of APNS in the immediate aftermath of trauma, and an inability to identify optimal treatments for individual patients. Our purpose is to provide a comprehensive review describing candidate blood-based biomarkers that may help to identify tho

SUBMITTER: Linnstaedt SD 

PROVIDER: S-EPMC7305050 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature