5-ALA-assistant automated detection of lymph node metastasis in gastric cancer patients.

ABSTRACT:

Background

5-aminolevulinic acid (5-ALA) has been utilized for cancer diagnosis as a fluorescence probe. We have reported the feasibility of 5-ALA-induced protoporphyrin IX (PpIX) fluorescence for detecting lymph node (LN) metastasis in gastrointestinal malignancies. However, a major barrier to the fluorescence diagnosis has been that the evaluation has been highly dependent on the observers. In this study, we examined the validity of a developed device for automated detection without subjectivity.

Methods

Gastric cancer patients who received oral administration of 5-ALA (20 mg/kg) prior to surgery were enrolled. For a total of 323 LNs obtained from 64 patients, the diagnostic results of the device were compared to those of conventional histopathological examination based on

SUBMITTER: Matsumoto T 

PROVIDER: S-EPMC7305096 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature