Radiomics for lung adenocarcinoma manifesting as pure ground-glass nodules: invasive prediction.

ABSTRACT:

Objectives

To investigate the value of radiomics based on CT imaging in predicting invasive adenocarcinoma manifesting as pure ground-glass nodules (pGGNs).

Methods

This study enrolled 395 pGGNs with histopathology-confirmed benign nodules or adenocarcinoma. A total of 396 radiomic features were extracted from each labeled nodule. A Rad-score was constructed with the least absolute shrinkage and selection operator (LASSO) in the training set. Multivariate logistic regression analysis was conducted to establish the radiographic model and the combined radiographic-radiomics model. The predictive performance was validated by receiver operating characteristic (ROC) curve. Based on the multivariate logistic regression analysis, an individual prediction nomogram was developed and

SUBMITTER: Sun Y 

PROVIDER: S-EPMC7305264 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature