The Archaeal Proteome Project advances knowledge about archaeal cell biology through comprehensive proteomics.

ABSTRACT: While many aspects of archaeal cell biology remain relatively unexplored, systems biology approaches like mass spectrometry (MS) based proteomics offer an opportunity for rapid advances. Unfortunately, the enormous amount of MS data generated often remains incompletely analyzed due to a lack of sophisticated bioinformatic tools and field-specific biological expertise for data interpretation. Here we present the initiation of the Archaeal Proteome Project (ArcPP), a community-based effort to comprehensively analyze archaeal proteomes. Starting with the model archaeon Haloferax volcanii, we reanalyze MS datasets from various strains and culture conditions. Optimized peptide spectrum matching, with strict control of false discovery rates, facilitates identifying > 72% of the reference proteom

SUBMITTER: Schulze S 

PROVIDER: S-EPMC7305310 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature