Brain functional connectivity during the first day of coma reflects long-term outcome.

ABSTRACT:

Objective

In patients with disorders of consciousness (DOC), properties of functional brain networks at rest are informative of the degree of consciousness impairment and of long-term outcome. Here we investigate whether connectivity differences between patients with favorable and unfavorable outcome are already present within 24 h of coma onset.

Methods

We prospectively recorded 63-channel electroencephalography (EEG) at rest during the first day of coma after cardiac arrest. We analyzed 98 adults, of whom 57 survived beyond unresponsive wakefulness. Functional connectivity was estimated by computing the 'debiased weighted phase lag index' over epochs of five seconds duration. We evaluated the network's topological features, including clustering coefficient, path length, mo

SUBMITTER: Kustermann T 

PROVIDER: S-EPMC7305428 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature