Lissencephaly in Shih Tzu dogs.

ABSTRACT:

Background

Lissencephaly is a brain malformation characterized by smooth and thickened cerebral surface, which may result in structural epilepsy. Lissencephaly is not common in veterinary medicine. Here, we characterize the first cases of lissencephaly in four Shih Tzu dogs, including clinical presentations and findings of magnetic resonance imaging of lissencephaly and several concomitant brain malformations.

Case presentation

Early-onset acute signs of forebrain abnormalities were observed in all dogs, which were mainly cluster seizures and behavioral alterations. Based on neurological examination, the findings were consistent with symmetrical and bilateral forebrain lesions. Metabolic disorders and inflammatory diseases were excluded. Magnetic resonance imaging for three

SUBMITTER: Rodriguez-Sanchez DN 

PROVIDER: S-EPMC7305484 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature