The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management.

ABSTRACT: The 2019 coronavirus disease (COVID-19) presents with a large variety of clinical manifestations ranging from asymptomatic carrier state to severe respiratory distress, multiple organ dysfunction and death. While it was initially considered primarily a respiratory illness, rapidly accumulating data suggests that COVID-19 results in a unique, profoundly prothrombotic milieu leading to both arterial and venous thrombosis. Consistently, elevated D-dimer level has emerged as an independent risk factor for poor outcomes, including death. Several other laboratory markers and blood counts have also been associated with poor prognosis, possibly due to their connection to thrombosis. At present, the pathophysiology underlying the hypercoagulable state is poorly understood. However, a growing body o

SUBMITTER: Abou-Ismail MY 

PROVIDER: S-EPMC7305763 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature