Local Perturbations of Cortical Excitability Propagate Differentially Through Large-Scale Functional Networks.

ABSTRACT: Electrophysiological recordings have established that GABAergic interneurons regulate excitability, plasticity, and computational function within local neural circuits. Importantly, GABAergic inhibition is focally disrupted around sites of brain injury. However, it remains unclear whether focal imbalances in inhibition/excitation lead to widespread changes in brain activity. Here, we test the hypothesis that focal perturbations in excitability disrupt large-scale brain network dynamics. We used viral chemogenetics in mice to reversibly manipulate parvalbumin interneuron (PV-IN) activity levels in whisker barrel somatosensory cortex. We then assessed how this imbalance affects cortical network activity in awake mice using wide-field optical neuroimaging of pyramidal neuron GCaMP dynamics as

SUBMITTER: Rosenthal ZP 

PROVIDER: S-EPMC7305790 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature