Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients.

ABSTRACT:

Background

The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a series of clinical symptoms and severe illnesses, including acute respiratory distress syndrome (ARDS) and fatal organ failure. We report the fundamental pathological investigation in the lungs and other organs of fatal cases for the mechanistic understanding of severe COVID-19 and the development of specific therapy in these cases.

Methods

The autopsy and pathological investigations of specimens were performed on bodies of two deceased cases with COVID-19. Gross anatomy and histological investigation by Hematoxylin and eosin (HE) stained were reviewed on each patient. Alcian blue/periodic acid-Schiff (AB-PAS) staining and Masson staining were performed for the examinations of

SUBMITTER: Wang C 

PROVIDER: S-EPMC7305897 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature