Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials.

ABSTRACT: Predicting what will happen in the future in terms of potential reward is essential in daily life. The aim of the current study was to investigate the neurotransmitter systems involved in the anticipation of reward value and probability. We hypothesized that dopaminergic and noradrenergic antagonism would affect anticipation of reward value and probability, respectively. Twenty-three healthy participants were included in a haloperidol (2 mg) × clonidine (0.150 mg) × placebo cross-over design and subjected to a Go/NoGo experimental task during which cues signaled the probability of subsequent target appearance. Reward value (amount of money that could be won for correct and fast responding to the target) as well as probability of target appearance was orthogonally manipulated across four ta

SUBMITTER: Schutte I 

PROVIDER: S-EPMC7306042 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature