Green Coffea arabica Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats.

ABSTRACT: Diabetes mellitus (DM) is a chronic endocrine disease characterized by persistent hyperglycemia. Oxidative damage, inflammatory cytokines, and apoptotic cell death play a major role in the induction and progression of male testicular damage. Plant-derived phytochemicals such as green coffee (Coffea arabica) can possess antidiabetic effects with little toxicity. The current study is aimed at investigating the therapeutic roles of green coffee in diabetic testicular injury stimulated by high-fat diet/streptozotocin administration. Diabetes mellitus was induced by a high-fat diet and a single dose of streptozotocin (STZ) (35 mg kg^-1) in male albino rats. Diabetic animals were orally given two different concentrations of green coffee (50 mg kg^-1 and 100 mg kg^-

SUBMITTER: Al-Megrin WA 

PROVIDER: S-EPMC7306074 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature