Serum neurotrophins at birth correlate with respiratory and neurodevelopmental outcomes of premature infants.

ABSTRACT:

Objective

Preterm birth is a significant cause of infant morbidity and mortality, which are primarily the result of respiratory and neurodevelopmental complications. However, no objective biomarker is currently available to predict at birth the risk and severity of such complications. Thus, we sought to determine whether serum neurotrophins concentrations measured at birth correlate with risk for later development of bronchopulmonary dysplasia (BPD) and long-term neurodevelopmental outcomes.

Methods

This study prospectively included 223 newborns admitted to neonatal intensive care units (NICU) and divided into three groups: (i) preterm infants who developed BPD; (ii) preterm infants who did not develop BPD; (iii) term infants. An exploratory cohort was enrolled in West Virgi

SUBMITTER: Simpson SL 

PROVIDER: S-EPMC7306099 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature