Paromomycin: A potential dual targeted drug effectively inhibits both spike (S1) and main protease of COVID-19.

ABSTRACT:

Objectives

With the increasing number of people suffering from coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a dire need to look for effective remedies against this pandemic. Drug repurposing seems to be the solution for the current situation.

Methods

In a quest to find a potential drug against this virus, 15 antimalarial drugs (including chloroquine) and 2413 US Food and Drug Administration-approved drugs were investigated for activity against both the protease and spike proteins of SARS-CoV-2 using an in silico approach. Molecular docking analysis followed by molecular dynamics simulation was performed to estimate the binding and stability of the complexes.

Results

This study identified a single

SUBMITTER: Tariq A 

PROVIDER: S-EPMC7306207 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature