Identification of hydatidosis-related modules and key regulatory genes.

ABSTRACT:

Background

Echinococcosis caused by larval of Echinococcus is prevalent all over the world. Although clinical experience showed that the presence of tapeworms could not be found in liver lesions, the repeated infection and aggravation of lesions still occur in the host. Here, this study constructed a multifactor-driven disease-related dysfunction network to explore the potential molecular pathogenesis mechanism in different hosts after E.multilocularis infection.

Method

First, iTRAQ sequencing was performed on human liver infected with E.multilocularis. Second, obtained microRNAs(miRNAs) expression profiles of humans and canine infected with Echinococcus from the GEO database. In addition, we also performed differential expression analysis,

SUBMITTER: Song J 

PROVIDER: S-EPMC7306218 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature