The Influence of Drug Properties and Ontogeny of Transporters on Pediatric Renal Clearance through Glomerular Filtration and Active Secretion: a Simulation-Based Study.

ABSTRACT: Glomerular filtration (GF) and active tubular secretion (ATS) contribute to renal drug elimination, with the latter remaining understudied across the pediatric age range. Therefore, we systematically analyzed the influence of transporter ontogeny on the relative contribution of GF and ATS to renal clearance CL_R for drugs with different properties in children. A physiology-based model for CL_R in adults was extrapolated to the pediatric population by including maturation functions for the system-specific parameters. This model was used to predict GF and ATS for hypothetical drugs with a range of drug-specific properties, including transporter-mediated intrinsic clearance (CL_int,T) values, that are substrates for renal secretion transporters with different ont

SUBMITTER: Cristea S 

PROVIDER: S-EPMC7306484 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature