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High-throughput photocapture approach for reaction discovery.

ABSTRACT: Modern organic reaction discovery and development relies on the rapid assessment of large arrays of hypothesis-driven experiments. The time-intensive nature of reaction analysis presents the greatest practical barrier for the execution of this iterative process that underpins the development of new bioactive agents. Toward addressing this critical bottleneck, we report herein a high-throughput analysis (HTA) method of reaction mixtures by photocapture on a 384-spot diazirine-terminated self-assembled monolayer, and self-assembled monolayers for matrix-assisted laser desorption/ionization mass spectrometry (SAMDI-MS) analysis. This analytical platform has been applied to the identification of a single-electron-promoted reductive coupling of acyl azolium species.

SUBMITTER: Bayly AA

PROVIDER: S-EPMC7306780 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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High-throughput photocapture approach for reaction discovery.

Bayly Alison A AA McDonald Benjamin R BR Mrksich Milan M Scheidt Karl A KA

Proceedings of the National Academy of Sciences of the United States of America 20200601 24

Modern organic reaction discovery and development relies on the rapid assessment of large arrays of hypothesis-driven experiments. The time-intensive nature of reaction analysis presents the greatest practical barrier for the execution of this iterative process that underpins the development of new bioactive agents. Toward addressing this critical bottleneck, we report herein a high-throughput analysis (HTA) method of reaction mixtures by photocapture on a 384-spot diazirine-terminated self-asse ...[more]

PMID: 32482866

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