Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal.

ABSTRACT: Precise control of organ growth and patterning is executed through a balanced regulation of progenitor self-renewal and differentiation. In the auditory sensory epithelium-the organ of Corti-progenitor cells exit the cell cycle in a coordinated wave between E12.5 and E14.5 before the initiation of sensory receptor cell differentiation, making it a unique system for studying the molecular mechanisms controlling the switch between proliferation and differentiation. Here we identify the Yap/Tead complex as a key regulator of the self-renewal gene network in organ of Corti progenitor cells. We show that Tead transcription factors bind directly to the putative regulatory elements of many stemness- and cell cycle-related genes. We also show that the Tead coactivator protein, Yap, is degraded spe

SUBMITTER: Gnedeva K 

PROVIDER: S-EPMC7306825 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature