Targeting Autophagy in Cancer: Recent Advances and Future Directions.

ABSTRACT: Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit the growth of established tumors and improve response to cancer therapeutics. Certain cancer genotypes may be especially prone to autophagy inhibition. Different strategies for autophagy modulation may be needed depending on the cancer context. Here, we review new advances in the molecular control of autophagy, the role of selective autophagy in cancer, and the role of autophagy within the tumor microenvironment and tumor immunity. We also highlight clinical efforts to repurpose lysosoma

SUBMITTER: Amaravadi RK 

PROVIDER: S-EPMC7306856 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature