A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression.

ABSTRACT: Since the outbreak of the COVID-19 pandemic, much has been learned regarding its clinical course, prognostic inflammatory markers, disease complications, and mechanical ventilation strategy. Clinically, three stages have been identified based on viral infection, pulmonary involvement with inflammation, and fibrosis. Moreover, low and high elastance phenotypes can be distinguished in mechanically ventilated patients, based on lung mechanics, ventilation-to-perfusion ratio, and CT scans; these two phenotypes have presumed differences in their underlying pathophysiology. Although essential for therapeutic guidance, the pathophysiology of COVID-19 is poorly understood. Here, we systematically reviewed published case reports and case series in order to increase our understanding of COVID-19 pat

SUBMITTER: Polak SB 

PROVIDER: S-EPMC7306927 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature