Gut microbiota of obese subjects with Prader-Willi syndrome is linked to metabolic health.

ABSTRACT:

Objective

The gut microbiota has been implicated in the aetiology of obesity and associated comorbidities. Patients with Prader-Willi syndrome (PWS) are obese but partly protected against insulin resistance. We hypothesised that the gut microbiota of PWS patients differs from that of non-genetically obese controls and correlate to metabolic health. Therefore, here we used PWS as a model to study the role of gut microbiota in the prevention of metabolic complications linked to obesity.

Design

We conducted a case-control study with 17 adult PWS patients and 17 obese subjects matched for body fat mass index, gender and age. The subjects were metabolically characterised and faecal microbiota was profiled by 16S ribosomal RNA gene sequencing. The patients' parents were used as a

SUBMITTER: Olsson LM 

PROVIDER: S-EPMC7306984 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature