Dataset Information

Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries.

ABSTRACT:

Objective

Ageing is accompanied by deterioration of multiple bodily functions and inflammation, which collectively contribute to frailty. We and others have shown that frailty co-varies with alterations in the gut microbiota in a manner accelerated by consumption of a restricted diversity diet. The Mediterranean diet (MedDiet) is associated with health. In the NU-AGE project, we investigated if a 1-year MedDiet intervention could alter the gut microbiota and reduce frailty.

Design

We profiled the gut microbiota in 612 non-frail or pre-frail subjects across five European countries (UK, France, Netherlands, Italy and Poland) before and after the administration of a 12-month long MedDiet intervention tailored to elderly subjects (NU-AGE diet).

Results

Adherence to the diet was associated with specific microbiome alterations. Taxa enriched by adherence to the diet were positively associated with several markers of lower frailty and improved cognitive function, and negatively associated with inflammatory markers including C-reactive protein and interleukin-17. Analysis of the inferred microbial metabolite profiles indicated that the diet-modulated microbiome change was associated with an increase in short/branch chained fatty acid production and lower production of secondary bile acids, p-cresols, ethanol and carbon dioxide. Microbiome ecosystem network analysis showed that the bacterial taxa that responded positively to the MedDiet intervention occupy keystone interaction positions, whereas frailty-associated taxa are peripheral in the networks.

Conclusion

Collectively, our findings support the feasibility of improving the habitual diet to modulate the gut microbiota which in turn has the potential to promote healthier ageing.

SUBMITTER: Ghosh TS

PROVIDER: S-EPMC7306987 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Publications

Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries.

Ghosh Tarini Shankar TS Rampelli Simone S Jeffery Ian B IB Santoro Aurelia A Neto Marta M Capri Miriam M Giampieri Enrico E Jennings Amy A Candela Marco M Turroni Silvia S Zoetendal Erwin G EG Hermes Gerben D A GDA Elodie Caumon C Meunier Nathalie N Brugere Corinne Malpuech CM Pujos-Guillot Estelle E Berendsen Agnes M AM De Groot Lisette C P G M LCPGM Feskins Edith J M EJM Kaluza Joanna J Pietruszka Barbara B Bielak Marta Jeruszka MJ Comte Blandine B Maijo-Ferre Monica M Nicoletti Claudio C De Vos Willem M WM Fairweather-Tait Susan S Cassidy Aedin A Brigidi Patrizia P Franceschi Claudio C O'Toole Paul W PW

Gut 20200217 7

<h4>Objective</h4>Ageing is accompanied by deterioration of multiple bodily functions and inflammation, which collectively contribute to frailty. We and others have shown that frailty co-varies with alterations in the gut microbiota in a manner accelerated by consumption of a restricted diversity diet. The Mediterranean diet (MedDiet) is associated with health. In the NU-AGE project, we investigated if a 1-year MedDiet intervention could alter the gut microbiota and reduce frailty.<h4>Design</h4 ...[more]

PMID: 32066625

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Dataset Information

Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries.

Objective

Design

Results

Conclusion

Publications

Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries.

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