Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components.

ABSTRACT: One of the key mechanisms used by cells to control the spatiotemporal organization of their many components is the formation and dissolution of biomolecular condensates through liquid-liquid phase separation (LLPS). Using a minimal coarse-grained model that allows us to simulate thousands of interacting multivalent proteins, we investigate the physical parameters dictating the stability and composition of multicomponent biomolecular condensates. We demonstrate that the molecular connectivity of the condensed-liquid network-i.e., the number of weak attractive protein-protein interactions per unit of volume-determines the stability (e.g., in temperature, pH, salt concentration) of multicomponent condensates, where stability is positively correlated with connectivity. While the connectivity o

SUBMITTER: Espinosa JR 

PROVIDER: S-EPMC7306995 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature