MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naive CD4⁺ T cells.

ABSTRACT: T cell maturation and activation depend upon T cell receptor (TCR) interactions with a wide variety of antigenic peptides displayed in a given major histocompatibility complex (MHC) context. Complementarity-determining region 3 (CDR3) is the most variable part of the TCRα and -β chains, which govern interactions with peptide-MHC complexes. However, it remains unclear how the CDR3 landscape is shaped by individual MHC context during thymic selection of naïve T cells. We established two mouse strains carrying distinct allelic variants of H2-A and analyzed thymic and peripheral production and TCR repertoires of naïve conventional CD4⁺ T (T_conv) and naïve regulatory CD4⁺ T (T_reg) cells. Compared with tuberculosis-resistant C57BL/6 (H2-A^b<

SUBMITTER: Logunova NN 

PROVIDER: S-EPMC7306996 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature