Association between BTLA polymorphisms and susceptibility to esophageal squamous cell carcinoma in the Chinese population.

ABSTRACT:

Background

Growing evidence suggested that B- and T-lymphocyte attenuator (BTLA) polymorphisms raised the susceptibility to a wide range of cancers. This study aimed to evaluate whether BTLA variants were related to the risk of esophageal squamous cell carcinoma (ESCC).

Methods

A total of 721 ESCC patients and 1208 matched non-cancer controls were included in this research, and four tagging BTLA polymorphisms (rs2171513 G > A, rs3112270 A > G, rs1982809 G > A, and rs16859629 T > C) were selected and genotyped using SNPscan™ Assays.

Results

In the present study, no significant relationship between BTLA polymorphisms and ESCC was observed. However, stratified analyses suggested that the variant of BTLA rs3112270 A > G reduced the risk of ESCC in the male subgroup (AG vs

SUBMITTER: Cao R 

PROVIDER: S-EPMC7307356 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature