ALKBH5 gene polymorphisms and Wilms tumor risk in Chinese children: A five-center case-control study.

ABSTRACT:

Background

Wilms tumor is a frequently diagnosed renal cancer among children with unclear genetic causes. N6-methyladenosine (m⁶ A) modification genes play critical roles in tumorigenesis. However, whether genetic variations of m⁶ A modification genes predispose to Wilms tumor remain unclear. ALKBH5 (AlkB homolog 5), a crucial member of m⁶ A modification genes, encodes a demethylase that functions to reverse m⁶ A RNA methylation.

Methods

Herein, we evaluated the association of single nucleotide polymorphisms (SNPs) in the m⁶ A modification gene ALKBH5 and Wilms tumor susceptibility in a large multi-center case-control study. A total of 414 Wilms tumor cases and 1199 healthy controls were genotyped for ALKBH5 rs1378602 an

SUBMITTER: Hua RX 

PROVIDER: S-EPMC7307367 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature