Significance of LncRNA CASC8 genetic polymorphisms on the tuberculosis susceptibility in Chinese population.

ABSTRACT:

Background

Tuberculosis remains an important disease threatening the security of public health, and no effective targets have been found for the immunological diagnosis or therapy of tuberculosis. The aim of this study was to explore the associations between lncRNA CASC8 genetic polymorphism and tuberculosis risk.

Method

A total of 900 tuberculosis patients and 1534 healthy individuals in the Western Chinese Han population were recruited for our study. Candidate SNPs of CASC8 were initially filtered by importing the 1000 genomes database into Haploview, and subsequently genotyped using modified multiplex ligation detection reactions.

Results

The lncRNA CASC8 genetic variant rs7836840 was associated with an increased tuberculosis risk with a P-value of .034, but .134 a

SUBMITTER: Liu G 

PROVIDER: S-EPMC7307370 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature