Putative functional variants of PI3K/AKT/mTOR pathway are associated with knee osteoarthritis susceptibility.

ABSTRACT:

Background

Osteoarthritis (OA) is a degenerative musculoskeletal disease which causes joint deformity and pain and finally leads to limb dysfunction. Knee osteoarthritis (KOA) has the highest incidence among all kinds of OA. Strong evidence leads to the understanding that P13K/AKT/mTOR signaling is very important in cartilage degeneration.

Methods

This research sought to understand the association between genetic variation of PI3K/AKT/mTOR genes and KOA susceptibility among Chinese population. All the genetic variants of PI3K/AKT/mTOR pathway were graded and selected using RegulomeDB database, and then, an association study including 278 osteoarthritis patients and 289 controls was conducted.

Results

Finally, eight SNPs' genotypes' distributions and susceptibility to

SUBMITTER: Wang K 

PROVIDER: S-EPMC7307371 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature