Two-way magnetic resonance tuning and enhanced subtraction imaging for non-invasive and quantitative biological imaging.

ABSTRACT: Distance-dependent magnetic resonance tuning (MRET) technology enables the sensing and quantitative imaging of biological targets in vivo, with the advantage of deep tissue penetration and fewer interactions with the surroundings as compared with those of fluorescence-based Förster resonance energy transfer. However, applications of MRET technology in vivo are currently limited by the moderate contrast enhancement and stability of T₁-based MRET probes. Here we report a new two-way magnetic resonance tuning (TMRET) nanoprobe with dually activatable T₁ and T₂ magnetic resonance signals that is coupled with dual-contrast enhanced subtraction imaging. This integrated platform achieves a substantially improved contrast enhancement with minimal background signal

SUBMITTER: Wang Z 

PROVIDER: S-EPMC7307456 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature