Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort.

ABSTRACT:

Background

Cockroach is one of the most important sources of indoor allergens and can lead to IgE sensitization and development of rhinitis and asthma.

Objective

We sought to perform a cockroach allergen component analysis to determine the allergens and antibody levels and patterns of sensitization associated with asthma and rhinitis.

Methods

Antibody (IgE, IgG, and IgG₄) levels to total cockroach and 8 cockroach allergens were determined in 2 groups of cockroach-sensitized 10-year-old children with (n = 19) or without (n = 28) asthma and rhinitis. Allergen-specific antibody levels were measured in streptavidin ImmunoCAPs loaded with each of the recombinant allergens from groups 1, 2, 4, 5, 6, 7, 9, and 11, and total cockroach-specific IgE levels were measu

SUBMITTER: Pomes A 

PROVIDER: S-EPMC7307589 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature