Hyperpolarized Metabolic Imaging Detects Latent Hepatocellular Carcinoma Domains Surviving Locoregional Therapy.

ABSTRACT:

Background and aims

Advances in cancer treatment have improved survival; however, local recurrence and metastatic disease-the principal causes of cancer mortality-have limited the ability to achieve durable remissions. Local recurrences arise from latent tumor cells that survive therapy and are often not detectable by conventional clinical imaging techniques. Local recurrence after transarterial embolization (TAE) of hepatocellular carcinoma (HCC) provides a compelling clinical correlate of this phenomenon. In response to TAE-induced ischemia, HCC cells adapt their growth program to effect a latent phenotype that precedes local recurrence.

Approach and results

In this study, we characterized and leveraged the metabolic reprogramming demonstrated by latent HCC cells in respon

SUBMITTER: Perkons NR 

PROVIDER: S-EPMC7307779 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature