Structural Neural Correlates of Impaired Postural Control in People with Secondary Progressive Multiple Sclerosis.

ABSTRACT:

Background

Secondary progressive multiple sclerosis (SPMS) is characterized by worsening of postural control and brain atrophy. However, little is known about postural deficits and their neuroanatomical correlates in this population. We aimed to determine the neuroanatomical correlates of postural deficits in people with SPMS and whether posture control deteriorates concomitantly with the brain and spinal cord atrophy in 2 years in SPMS.

Methods

This study is a post hoc analysis of data from 27 people with SPMS (mean ± SE age, 58.6 ± 1.1 years). Participants had magnetic resonance imaging (MRI) of the brain and cervical spinal cord followed by sway testing using inertial sensors during standing with eyes open (EO) and eyes closed without (EC) and with (ECC) a cognitive task.

SUBMITTER: Arpan I 

PROVIDER: S-EPMC7307870 | biostudies-literature | 2020 May-Jun

REPOSITORIES: biostudies-literature