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Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions.

ABSTRACT: In this contribution, we report novel palladium-catalyzed carbonylative cascade approaches to highly functionalized polyheterocyclic structures. The Pd-catalyzed carbonylative process involves the regioselective insertion of one to three CO molecules and the sequential ordered formation of up to eight new bonds (one C-O, two C-C, five C-N). The exclusive formation of six-membered heterocycles is elucidated by detailed modeling studies.

SUBMITTER: Pancrazzi F

PROVIDER: S-EPMC7307965 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Site-Selective Double and Tetracyclization Routes to Fused Polyheterocyclic Structures by Pd-Catalyzed Carbonylation Reactions.

Pancrazzi Francesco F Sarti Nicolò N Mazzeo Paolo P PP Bacchi Alessia A Carfagna Carla C Mancuso Raffaella R Gabriele Bartolo B Costa Mirco M Stirling András A Della Ca' Nicola N

Organic letters 20200203 4

In this contribution, we report novel palladium-catalyzed carbonylative cascade approaches to highly functionalized polyheterocyclic structures. The Pd-catalyzed carbonylative process involves the regioselective insertion of one to three CO molecules and the sequential ordered formation of up to eight new bonds (one C-O, two C-C, five C-N). The exclusive formation of six-membered heterocycles is elucidated by detailed modeling studies. ...[more]

PMID: 32011899

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