Long intergenic noncoding RNAs in cardiovascular diseases: Challenges and strategies for physiological studies and translation.

ABSTRACT: Long intergenic noncoding RNAs (lincRNAs) are increasingly recognized as important mediators of many biological processes relevant to human pathophysiologies, including cardiovascular diseases. In vitro studies have provided important knowledge of cellular functions and mechanisms for an increasing number of lincRNAs. Dysregulated lncRNAs have been associated with cell fate programming and development, vascular diseases, atherosclerosis, dyslipidemia and metabolic syndrome, and cardiac pathological hypertrophy. However, functional interrogation of individual lincRNAs in physiological and disease states is largely limited. The complex nature of lincRNA actions and poor species conservation of human lincRNAs pose substantial challenges to physiological studies in animal model systems and in

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7307970 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature