Placental transfer and safety in pregnancy of medications under investigation to treat coronavirus disease 2019.

ABSTRACT:

Objective

Treatment of coronavirus disease 2019 is mostly symptomatic, but a wide range of medications are under investigation against severe acute respiratory syndrome coronavirus 2. Although pregnant women are excluded from clinical trials, they will inevitably receive therapies whenever they seem effective in nonpregnant patients and even under compassionate use.

Methods

We conducted a review of the literature on placental transfer and pregnancy safety data of drugs under current investigation for coronavirus disease 2019.

Results

Regarding remdesivir, there are no data in pregnant women. Several other candidates already have safety data in pregnant women, because they are repurposed drugs already used for their established indications. Thus, they may be used in pr

SUBMITTER: Louchet M 

PROVIDER: S-EPMC7308040 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature