Efficacy and Safety of VisuEvo^® and Cationorm^® for the Treatment of Evaporative and Non-Evaporative Dry Eye Disease: A Multicenter, Double-Blind, Cross-Over, Randomized Clinical Trial.

ABSTRACT:

Purpose

To compare the efficacy of the new lubricating product VisuEvo^® (VSE) vs Cationorm^® (CTN) in patients with dry eye disease (DED).

Methods

Seventy-two patients with evaporative (n=54) and non-evaporative DED (n=18) were included in a multicenter, double-blind, 12-week cross-over study to receive VSE (6 weeks) and CTN (6 weeks) in randomized sequence. After baseline, two visits were performed during each period (intermediate and final visit, respectively at 2 and 6 weeks from the beginning of each period). Primary (tear break-up time, TBUT) and secondary endpoints (Schirmer I, Ferning, blink rate, osmometry, cytokine and lipid expression, ocular surface staining, patient satisfaction, and OSDI score) were compared.

Results

Sixty-three patie

SUBMITTER: Fogagnolo P 

PROVIDER: S-EPMC7308118 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature