Prescribing Patterns and Patient Outcomes for Bone and Joint Infections Treated with Cefazolin and Probenecid: A Retrospective Observational Study.

ABSTRACT:

Background

Previous studies have described the use of cefazolin with probenecid to treat uncomplicated skin and soft-tissue infections. Some prescribers are extrapolating from this evidence to treat more invasive infections, which have a greater potential for poor outcomes, including treatment failure that could lead to increased morbidity and mortality. Information supporting cefazolin with probenecid as effective treatment in this context is needed.

Objectives

To describe prescribing patterns and outcomes for patients who received cefazolin with probenecid for the treatment of bone and joint infections.

Methods

This single-centre retrospective study involved adult outpatients for whom cefazolin and probenecid were prescribed for bone and joint infections between Apr

SUBMITTER: Dearing ME 

PROVIDER: S-EPMC7308159 | biostudies-literature | 2020 May-Jun

REPOSITORIES: biostudies-literature