Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes.

ABSTRACT:

Background

Cysteinyl leukotrienes (CysLTs) are potent prophlogistic mediators in asthmatic patients; however, inhibition of CysLT receptor 1 is not a consistently effective treatment, suggesting additional regulatory mechanisms. Other cysteinyl-containing lipid mediators (LMs) derived from docosahexaenoic acid, namely maresin conjugates in tissue regeneration (MCTRs), were recently discovered. Therefore their production and actions in the lung are of considerable interest.

Objective

We sought to determine MCTR production, bioactions, and mechanisms in the human lung and in patients with experimental allergic airway inflammation.

Methods

LM metabololipidomic profiling of the lung was performed by using liquid chromatography with tandem mass spectrometry. Donor-derived

SUBMITTER: Levy BD 

PROVIDER: S-EPMC7308163 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature