Basement membrane remodelling regulates mouse embryogenesis.

ABSTRACT: Tissue sculpting during development has been attributed mainly to cellular events through processes such as convergent extension or apical constriction^1,2. However, recent work has revealed roles for basement membrane remodelling in global tissue morphogenesis^3-5. Upon implantation, the epiblast and extraembryonic ectoderm of the mouse embryo become enveloped by a basement membrane. Signalling between the basement membrane and these tissues is critical for cell polarization and the ensuing morphogenesis^6,7. However, the mechanical role of the basement membrane in post-implantation embryogenesis remains unknown. Here we demonstrate the importance of spatiotemporally regulated basement membrane remodelling during early embryonic development. Specifically, we

SUBMITTER: Kyprianou C 

PROVIDER: S-EPMC7308173 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature