Effects of repeated treatment with monoamine-transporter-inhibitor antidepressants on pain-related depression of intracranial self-stimulation in rats.

ABSTRACT:

Rationale

Synaptic neurotransmission with dopamine (DA), norepinephrine (NE), and serotonin (5-HT) is terminated primarily by reuptake into presynaptic terminals via the DA, NE, and 5-HT transporters (DAT/NET/SERT, respectively). Monoamine transporter inhibitors constitute one class of drugs used to treat both depression and pain, and therapeutic effects by these compounds often require repeated treatment for days or weeks.

Objectives

The present study compared antinociceptive effects produced by repeated treatment with monoamine transporter inhibitors in a preclinical assay of pain-related depression of positively reinforced operant responding.

Methods

Adult Sprague-Dawley rats equipped with microelectrodes targeting a brain-reward area responded for pulses of electr

SUBMITTER: Legakis LP 

PROVIDER: S-EPMC7308219 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature