Microevolution of Campylobacter jejuni during long-term infection in an immunocompromised host.

ABSTRACT: Campylobacteriosis typically manifests as a short-lived, self-limiting gastrointestinal infection in humans, however prolonged infection can be seen in cases with underlying immunodeficiency. Public Health England received 25 isolates of Campylobacter jejuni from an individual with combined variable immunodeficiency over a period of 15 years. All isolates were typed and archived at the time of receipt. Whole genome sequencing (WGS) and antimicrobial susceptibility testing were performed to examine the relatedness of the isolates and to investigate the changes in the genome that had taken place over the course of the infection. Genomic typing methods were compared to conventional phenotypic methods, and revealed that the infection was caused by a single, persistent strain of C. jejuni belon

SUBMITTER: Barker CR 

PROVIDER: S-EPMC7308304 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature