Ontology highlight
ABSTRACT:
SUBMITTER: Collins PL
PROVIDER: S-EPMC7308414 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nature communications 20200622 1
Efficient repair of DNA double-strand breaks (DSBs) requires a coordinated DNA Damage Response (DDR), which includes phosphorylation of histone H2Ax, forming γH2Ax. This histone modification spreads beyond the DSB into neighboring chromatin, generating a DDR platform that protects against end disassociation and degradation, minimizing chromosomal rearrangements. However, mechanisms that determine the breadth and intensity of γH2Ax domains remain unclear. Here, we show that chromosomal contacts o ...[more]