Treatment advantage in HBV/HIV coinfection compared to HBV monoinfection in a South African cohort.

ABSTRACT:

Objectives

Prompted by international targets for elimination of hepatitis B virus (HBV), we set out to characterise individuals with HBV monoinfection vs. those coinfected with HBV/HIV, to evaluate the impact of therapy and to guide improvements in clinical care.

Methods

We report observational data from a real world cross-sectional cohort of 115 adults with chronic hepatitis B infection (CHB), at a university hospital in Cape Town, South Africa. HIV coinfection was present in 39 (34%) subjects. We recorded cross-sectional demographic, clinical and laboratory data.

Results

Compared to those with HIV coinfection, HBV monoinfected adults were less likely to be HBeAg-positive (p=0.01), less likely to have had assessment with elastography (p<0.0001), and less likely to be

SUBMITTER: Maponga TG 

PROVIDER: S-EPMC7308798 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature