Investigation of syphilis immunology and Treponema pallidum subsp. pallidum biology to improve clinical management and design a broadly protective vaccine: study protocol.

ABSTRACT:

Background

The syphilis epidemic continues to cause substantial morbidity and mortality worldwide, particularly in low- and middle-income countries, despite several recent disease control initiatives. Though our understanding of the pathogenesis of this disease and the biology of the syphilis agent, Treponema pallidum subsp. pallidum has improved over the last two decades, further research is necessary to improve clinical diagnosis and disease management protocols. Additionally, such research efforts could contribute to the identification of possible targets for the development of an effective vaccine to stem syphilis spread.

Methods

This study will recruit two cohorts of participants with active syphilis infection, one with de novo infection, one with repeat infection. Whol

SUBMITTER: Osias E 

PROVIDER: S-EPMC7309211 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature