Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multisite cohort.

ABSTRACT:

Background

There is strong evidence for a role of type 2 cytokines in the pathogenesis of eosinophilic esophagitis (EoE); however, heterogeneity in type 2 gene expression has not been examined.

Objective

We examined type 2 immunity-associated gene expression in esophageal biopsy specimens, aiming to determine the degree of cytokine heterogeneity and its potential clinical significance.

Methods

Patients (n = 312) were recruited from 10 sites associated with the Consortium of Eosinophilic Gastrointestinal Disease Researchers. In addition to histologic and endoscopic assessment, esophageal biopsy specimens were examined for expression of 96 genes within the EoE diagnostic panel.

Results

Five subgroups of patients with active EoE were identified by unsupervised clu

SUBMITTER: Dunn JLM 

PROVIDER: S-EPMC7309223 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature